Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli “Federico II”, 80131 Napoli, Italy
Helicobacter pylori (H. pylori) is a Gram-negative microaerophilic spiral bacterium previously known as Campylobacter pylori. Since the discovery of H. pylori as a pathogenic infectious agent in humans, it has been linked to different gastric diseases in humans (gastritis, peptic ulcers, gastric adenocarcinoma, and MALT lymphoma).
It colonizes the gastrointestinal mucosa of its host, and in spite of a strong persistent humoral and cellular immune response to H. pylori at the local and systemic level, the organism persists for the lifetime of its host.
The study of the host defense mechanisms factors of the bacteria is key to detection of the molecular and cellular pathways involved and will lead to developing preventive and therapeutic modules in which antibiotic eradication provides a clinical benefit, mainly for gastric diseases.
The increase in the use of antimicrobial therapy has driven to the development and emergence of resistance to the antibiotics used, which leads to a public health problem.
The aim of this Special Issue is to update the biological and clinical concepts of the H. pylori infection.
We warmly invite you to submit your research articles, reviews, and short communications related to the different aspects of H. pylori infection and host defense mechanism: epidemiology, clinical complications, pathogenesis, environmental factors, host genetic susceptibility and immune profile, pattern recognition receptors, cytokines, diagnosis, prevention, and therapy.
Per maggiori informazioni https://www.mdpi.com/journal/microorganisms/special_issues/helicobacterpylori#info