Natural antimicrobial compounds
In recent years, the emergence of microbial and viral infections associated with multidrug-resistant and biofilm-forming microorganisms has become one of the biggest challenges to fight in the medical field. Moreover, of particular concern is that some preservative-resistant bacterial strains isolated from cosmetic products show a degree of cross-resistance with antibiotics.
In addition to resistance, with the growing immunocompromised population due to organ transplant, chemotherapy, and AIDS, the frequency of microbial and viral infections has sharply increased. All the above-mentioned situations together with a limited arsenal of antimicrobial and antiviral drugs and agents encourage the development of new therapeutic approaches to combat microbial and viral infections. Various strategies have been suggested and one of these has involved natural products with antimicrobial properties or that have the ability to enhance the activity of an antibiotic in combination with them. Novel or long-known natural products alone or combined with nanoformulations have always offered good prospects for the development and discovery of therapeutics or preservatives over the past decades and still play an important role in pharmaceutical and other industries innovation. This Special Issue aims to highlight the latest advances and developments also associated with nanotechnology and therapeutic benefits related to the use of natural products and/or isolated compounds alone or in association with conventional drugs for microbial infections.
Both in vitro and in vivo studies are encouraged. The detailed chemical analysis of the natural compounds should be presented such as well as their toxicity.
We invite authors who are leading experts in this field to contribute with original articles that are not yet published or that are not currently under review by other journals and to promote, integrate, and disseminate them. Review articles which describe the current state of the research on this topic are also welcome. The publication of articles on this special issue should provide a forum for researchers to share their recent findings and offer exposure of the published articles to the scientific community. We hope that this special issue will advance knowledge and stimulate new collaborations and new research directions.
The following topics included will concern:
- Natural products and/or isolated compounds active against microorganisms and virus.
- Natural products and/or isolated compounds active against microbial biofilms.
- Chemical characterization of antimicrobial natural products and/or isolated compounds active against microorganisms.
- Toxicity studies in vitro and/or in vivo.
- Natural products and/or isolated compounds active against microorganisms in association with conventional drugs.
- Elucidation of the mechanism of action of natural products and/or isolated compounds active against microorganisms alone or in combination with conventional drugs.
- Novel nanoformulations for the delivery of natural products and/or isolated compounds active against microorganisms.
Keywords: antimicrobial natural products, natural isolated compounds active against microorganisms, biofilm, antimicrobial natural products in combination with drugs or preservatives, chemical characterization, toxicity, mechanism of action, nanoformulations
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy. firstname.lastname@example.org
Department of Department of Environmental Biology, “Sapienza” University of Rome, Italy