Molecules special issue: “Novel Biologically Active Molecules, Biomaterials and Nanoparticles for the Microbial Biofilm Control in Human Medicine”
Dear Colleagues, Microbial biofilms are complex structures formed by cells embedded in an extracellular polymeric substance (EPS) matrix, a mixture of macromolecules such as exopolysaccharides; proteins; extracellular DNA; and, in some cases, outer membrane vesicles. EPS composition may differ with bacterial strains, culture conditions, and biofilm age. Biofilm formation ensures antibiotic tolerance and protection from the host immune system, making microbial biofilms difficult to eradicate. Biofilms are responsible for chronic infections, and biofilms developed by a wide range of microorganisms are considered a “virulence factor”. The variability in the composition of the biofilm matrix and in biofilm development as well as [...]